To add an enzyme toothpaste can prevent tooth decay

According to recent reports, two professors of Groningen, Dijkstra and Di Jike Hao Cen decipher the cause of tooth decay glucanase structure and mechanism. This knowledge will further contain substances that inhibit the enzyme identification and discovery. As long as this kind of material added to toothpaste and even candy, you can prevent tooth decay, tooth decay will become the past.

The study's results have been published in the National Academy of Sciences journal, researchers from the University of Groningen, the Netherlands lactic acid bacteria - Lactobacillus in the analysis of glucan Luoyi Shi, Luo Yishi Lactobacillus in the human mouth and dental supplies digestive tract. The bacteria use glucanase sugar in food into long, with the adhesion of the sugar chain. And use of this sugar chain adhesion to the enamel on their own adhesive. The initiator of the tooth decay Streptococcus mutans, also use this enzyme. Once attached to the tooth surface, these bacteria release acids will dissolve the sugar fermentation in the teeth of calcium, which is the process of dental caries.

Crystal structure shows that the protein folding mechanism is unique. Domain of this enzyme is not a linear chain of amino acids by a single form, but from two parts, the two parts U-shaped structure to chain together. With the three-dimensional structure of the crack, the researchers found that the enzyme will be broken down into fructose and glucose substance, and What are the common methods of denture then to add the growing sugar chain of glucose molecules. So far, scientists think that these two processes is carried out in different parts of the enzyme. However, researchers from the Groningen model established that both activities occur in the same enzyme active site.

Glucanase specific inhibitors may help prevent the bacteria attached to the enamel on. The structure and function of this enzyme mechanisms information on the development of this inhibitor is essential. So far, this study also did not succeed. Through the study of various inhibitors, they not only inhibit glucanase, but also to inhibit the digestion of starch enzymes.